Prostaglandin D synthase

Prostaglandin D synthase (PGDS) is an enzyme that in humans is encoded by the PTGDS gene. It is involved in the production of prostaglandin D2 (PGD2), a potent lipid mediator that plays a significant role in various biological functions such as sleep regulation, body temperature maintenance, and inflammation response.

Function

Prostaglandin D synthase is a sigma class glutathione S-transferase family member. The enzyme catalyzes the conversion of prostaglandin H2 to prostaglandin D2, a major biological active product of cyclooxygenase (COX). PGD2 functions as a neurotransmitter or a neuroendocrine hormone. It is involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation.

Clinical significance

Alterations in the PTGDS gene have been associated with various diseases, including asthma, allergies, autoimmune diseases, and cancer. In the central nervous system, PGDS has been implicated in sleep disorders, Alzheimer's disease, and other neurodegenerative diseases.

See also

• Prostaglandin
• Prostaglandin-endoperoxide synthase
• Prostaglandin E synthase
• Prostaglandin F synthase

External links

• GeneCards - PTGDS

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