Proximal convoluted tubule

Proximal Convoluted Tubule

The Proximal Convoluted Tubule (PCT) is a part of the nephron in the kidney. It is the first part of the renal tubule and plays a significant role in the functioning of the kidney.

Structure

The PCT is a tube in the kidney cortex that extends from the Bowman's capsule to the descending limb of the Loop of Henle. It is surrounded by peritubular capillaries, which are branches of the efferent arteriole.

Function

The primary function of the PCT is to reabsorb about 65% of the glomerular filtrate. This includes water, sodium, chloride, potassium, glucose, amino acids, and bicarbonate. It also secretes hydrogen ions, ammonium ions, and certain drugs into the filtrate.

Clinical significance

Diseases that affect the PCT can lead to serious health problems. For example, Fanconi syndrome is a disease in which the PCT fails to reabsorb nutrients, leading to their loss in the urine.

See also

• Distal convoluted tubule
• Renal physiology
• Renal tubular acidosis

References

Proximal convoluted tubule Resources
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