Purple glove syndrome

Purple glove syndrome (PGS) is a rare but serious complication associated with the intravenous administration of the anticonvulsant drug phenytoin. It is characterized by the development of painful swelling, discoloration, and sometimes tissue necrosis in the affected limb.

Presentation

Purple glove syndrome typically presents within hours to days after the administration of phenytoin. The affected area, usually the hand or arm, initially shows a purple discoloration, which can progress to more severe symptoms including:

• Pain and tenderness
• Swelling
• Blistering
• Tissue necrosis

Pathophysiology

The exact mechanism of PGS is not well understood. However, it is believed to be related to the extravasation of phenytoin into the surrounding tissues, leading to local irritation and vascular damage. Factors that may contribute to the development of PGS include:

• High pH of phenytoin solution
• Rapid infusion rates
• Use of small veins for administration

Diagnosis

Diagnosis of purple glove syndrome is primarily clinical, based on the characteristic appearance of the affected limb and the history of recent phenytoin administration. Imaging studies such as ultrasound or MRI may be used to assess the extent of tissue damage.

Management

Management of PGS involves discontinuation of phenytoin and supportive care. Treatment options may include:

• Elevation of the affected limb
• Application of warm compresses
• Pain management with analgesics
• Surgical intervention in severe cases, such as fasciotomy or debridement

Prevention

Preventive measures to reduce the risk of PGS include:

• Using alternative routes of administration for phenytoin, such as oral or intramuscular
• Administering phenytoin through a central venous catheter
• Slowing the infusion rate and diluting the phenytoin solution

Related Pages

• Phenytoin
• Intravenous therapy
• Tissue necrosis
• Anticonvulsant

See Also

• Extravasation (intravenous)
• Compartment syndrome
• Drug-induced skin reactions

Resources

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Purple glove syndrome for any updates.

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