Pyrazolam

A benzodiazepine derivative

Pyrazolam
File:Pyrazolam structure.png
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CAS Number	39241-27-5
PubChem	9827100
DrugBank
ChemSpider	8003030
KEGG

Pyrazolam is a benzodiazepine derivative that was first synthesized in the 1970s. It is known for its anxiolytic properties and is used primarily in research settings. Unlike many other benzodiazepines, pyrazolam is not commonly prescribed for therapeutic use.

Chemical Structure and Properties

Pyrazolam belongs to the triazolobenzodiazepine class, which is characterized by the fusion of a triazole ring to the benzodiazepine structure. The chemical formula for pyrazolam is C₁₆H₁₂BrN₅. It is structurally related to other benzodiazepines such as alprazolam and bromazepam.

Pharmacology

Pyrazolam acts as a positive allosteric modulator of the [[GABA_A receptor]], which enhances the effect of the neurotransmitter gamma-aminobutyric acid (GABA). This action results in increased inhibitory neurotransmission in the brain, leading to its anxiolytic effects. Pyrazolam has a high affinity for the benzodiazepine site on the GABA_A receptor, which contributes to its potency.

Effects

The primary effects of pyrazolam include:

• Anxiolytic: Reduction of anxiety and stress.
• Sedative: Induction of calmness and relaxation.
• Muscle relaxant: Reduction of muscle tension.

Unlike some other benzodiazepines, pyrazolam is reported to have minimal hypnotic effects, making it less likely to induce sleep.

Usage

Pyrazolam is not approved for medical use in most countries and is primarily used in research settings to study the effects of benzodiazepines on the central nervous system. It is sometimes encountered in the designer drug market, where it is sold as a research chemical.

Legal Status

The legal status of pyrazolam varies by country. In some jurisdictions, it is classified as a controlled substance, while in others, it remains unscheduled. Researchers and users should be aware of the legal implications of possessing or using pyrazolam in their respective regions.

Safety and Toxicity

As with other benzodiazepines, the use of pyrazolam carries the risk of dependence and withdrawal symptoms. Overdose can lead to severe central nervous system depression, respiratory depression, and potentially fatal outcomes. Caution is advised when using pyrazolam, especially in combination with other central nervous system depressants such as alcohol or opioids.

Related Pages

• Benzodiazepine
• [[GABA_A receptor]]
• Anxiolytic
• Triazolobenzodiazepine