Pyroglutamylated RFamide peptide receptor
Pyroglutamylated RFamide Peptide Receptor[edit | edit source]
The Pyroglutamylated RFamide Peptide Receptor (QRFPR) is a G protein-coupled receptor (GPCR) that is activated by the neuropeptide QRFP. This receptor is involved in various physiological processes, including the regulation of appetite, metabolism, and cardiovascular function.
Structure[edit | edit source]
QRFPR is a member of the G protein-coupled receptor family, which is characterized by seven transmembrane domains. These receptors are integral membrane proteins that transmit signals from extracellular ligands to intracellular G proteins.
Function[edit | edit source]
The primary function of the QRFPR is to bind the neuropeptide QRFP, also known as 26RFa, which is involved in the regulation of energy homeostasis and feeding behavior. Activation of QRFPR by QRFP leads to various downstream effects, including the modulation of hormone secretion and neuronal activity.
Expression[edit | edit source]
QRFPR is expressed in several tissues, including the brain, heart, and adipose tissue. Its expression in the hypothalamus is particularly important for its role in regulating appetite and energy balance.
Clinical Significance[edit | edit source]
Alterations in QRFPR signaling have been implicated in obesity and metabolic disorders. Understanding the role of QRFPR in these conditions could lead to the development of new therapeutic strategies for managing obesity and related metabolic diseases.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
