Pyroglutamylated RFamide peptide receptor

Pyroglutamylated RFamide peptide receptor (QRFPR), also known as G-protein coupled receptor 103 (GPR103), is a protein that in humans is encoded by the QRFPR gene. It is a member of the G protein-coupled receptor family, a large group of proteins that play a role in many different physiological functions.

Function

The QRFPR gene encodes a protein that is a member of the rhodopsin family of G protein-coupled receptors. These receptors are integral membrane proteins that contain seven transmembrane domains and are involved in many different physiological functions. The encoded protein is a receptor for pyroglutamylated RFamide peptide (QRFP), and functions in appetite regulation.

Clinical significance

Alterations in the QRFPR gene have been associated with obesity and eating disorders. Studies have shown that QRFP and its receptor may play a role in the regulation of energy homeostasis and obesity.

See also

• G protein-coupled receptor
• Rhodopsin
• Obesity
• Eating disorders

External links

• Human QRFPR gene details page in the National Center for Biotechnology Information (NCBI) website.

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