Quinprenaline

A sympathomimetic bronchodilator

Quinprenaline
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Quinprenaline is a sympathomimetic drug that acts as a bronchodilator. It is primarily used in the treatment of asthma and other conditions associated with bronchospasm. Quinprenaline functions by stimulating beta-adrenergic receptors, leading to the relaxation of bronchial smooth muscle and subsequent dilation of the airways.

Pharmacology

Quinprenaline is a selective beta-2 adrenergic receptor agonist. By binding to these receptors, it mimics the action of epinephrine and norepinephrine, which are naturally occurring catecholamines in the body. This action results in the activation of adenylate cyclase, increasing the levels of cyclic adenosine monophosphate (cAMP) within cells. Elevated cAMP levels lead to the relaxation of smooth muscle tissues, particularly in the bronchi, thereby alleviating symptoms of bronchoconstriction.

Clinical Use

Quinprenaline is administered to patients experiencing acute episodes of bronchospasm, such as those occurring in asthma or chronic obstructive pulmonary disease (COPD). It is often delivered via inhalation, which allows for rapid onset of action and direct delivery to the lungs, minimizing systemic side effects.

Side Effects

Common side effects of quinprenaline include tremor, tachycardia, and nervousness. These effects are generally mild and result from the systemic activation of beta-adrenergic receptors. In some cases, patients may experience palpitations, headache, or dizziness.

Mechanism of Action

Structural formula of Quinprenaline

Quinprenaline's mechanism of action involves the selective stimulation of beta-2 adrenergic receptors located in the bronchial smooth muscle. This selectivity helps to minimize cardiovascular side effects that are more common with non-selective beta agonists. The increase in cAMP levels leads to the activation of protein kinase A (PKA), which phosphorylates target proteins, resulting in muscle relaxation and bronchodilation.

Chemical Properties

Quinprenaline is a phenethylamine derivative, characterized by the presence of a catechol group, which is essential for its activity as a beta-adrenergic agonist. The chemical structure of quinprenaline allows it to interact effectively with beta-2 adrenergic receptors, providing its therapeutic effects.

Related Pages

• Beta-2 adrenergic receptor
• Bronchodilator
• Asthma
• Chronic obstructive pulmonary disease