RI-1 (chemical)

RI-1 is a chemical compound that is used in the field of pharmacology. It is a small molecule inhibitor of RAD51, a protein that plays a key role in the process of DNA repair and recombination. RI-1 has been shown to inhibit RAD51's ability to form filaments, thereby disrupting its function and potentially making cells more susceptible to DNA damage.

Chemical Structure

RI-1 is a small molecule with a molecular weight of 312.35 g/mol. Its chemical formula is C17H16N2O3. The compound is composed of a benzene ring attached to a pyrrole ring, with an amide group and a nitro group attached to the pyrrole ring.

Mechanism of Action

RI-1 acts by binding to the RAD51 protein and inhibiting its ability to form filaments. This disrupts the protein's function in DNA repair and recombination. The exact binding site and mechanism of action of RI-1 are still under investigation.

Pharmacological Applications

Due to its ability to inhibit RAD51, RI-1 has potential applications in the treatment of cancer. Many types of cancer cells are known to overexpress RAD51, and inhibiting this protein could potentially make these cells more susceptible to DNA damage and cell death. However, further research is needed to fully understand the potential benefits and risks of using RI-1 in cancer treatment.

Safety and Toxicity

The safety and toxicity of RI-1 are not fully understood. As with any chemical compound, exposure to RI-1 should be handled with care to avoid potential health risks.

See Also

• RAD51
• DNA repair
• Cancer treatment

References

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