RTI-229
RTI-229 is a tropane derivative drug that acts as a dopamine reuptake inhibitor and has been researched for use in treating cocaine addiction. It is a potent and selective DAT inhibitor, with a Ki of 0.16 nM, and is around 5x more potent than cocaine at inhibiting dopamine reuptake, although it produces significantly less locomotor stimulation in animals. It is named after the Research Triangle Institute (RTI), and is part of the phenyltropane group of compounds.
Pharmacology[edit | edit source]
RTI-229 is a phenyltropane based, highly potent and selective DAT inhibitor. It is around 5x more potent than cocaine at inhibiting dopamine reuptake. However, it produces significantly less locomotor stimulation in animals, which suggests a lower potential for recreational use.
Potential Medical Uses[edit | edit source]
RTI-229 has been researched for use in treating cocaine addiction. The drug's high potency and selectivity for the DAT over other targets make it a promising candidate for this application. However, further research is needed to fully understand its potential benefits and risks.
See Also[edit | edit source]
RTI-229 Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD