Racefemine

Chemical compound

Racefemine
INN
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Routes of administration
Pregnancy category
Bioavailability
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Elimination half-life
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Legal status
CAS Number	15301-48-1
PubChem	68873
DrugBank
ChemSpider	62073
KEGG	D07395

Racefemine is a nonsteroidal anti-inflammatory drug (NSAID) that is used primarily for its analgesic and anti-inflammatory properties. It is a racemic mixture of two enantiomers, which are mirror images of each other. The drug is known for its ability to alleviate pain and reduce inflammation in various conditions.

Pharmacology

Racefemine works by inhibiting the cyclooxygenase (COX) enzymes, which are responsible for the formation of prostaglandins. Prostaglandins are lipid compounds that have several important roles in the body, including the mediation of inflammation and pain. By reducing the production of prostaglandins, racefemine helps to decrease inflammation and alleviate pain.

Chemical Structure

Structural formula of Racefemine

The chemical structure of racefemine includes a trifluoroethoxy group attached to a phenyl ring, which is connected to an acetamide group. This structure is responsible for its pharmacological activity as an NSAID. The presence of the trifluoromethyl group is significant as it can influence the drug's metabolic stability and its interaction with biological targets.

Uses

Racefemine is used in the treatment of various conditions that involve pain and inflammation. These include:

• Arthritis
• Musculoskeletal pain
• Postoperative pain

Side Effects

As with other NSAIDs, racefemine can cause a range of side effects. Common side effects include:

• Gastrointestinal discomfort
• Nausea
• Dizziness

More serious side effects can occur, such as gastrointestinal bleeding and renal impairment, especially with long-term use.

Mechanism of Action

Racefemine's mechanism of action involves the non-selective inhibition of COX-1 and COX-2 enzymes. COX-1 is involved in the protection of the stomach lining and maintenance of kidney function, while COX-2 is primarily involved in inflammation and pain. The inhibition of these enzymes leads to reduced synthesis of prostaglandins, thereby reducing inflammation and pain.

Related pages

• Nonsteroidal anti-inflammatory drug
• Cyclooxygenase
• Prostaglandin