RepSox
RepSox is a small molecule inhibitor that has been identified as a potent inducer of embryonic stem cell (ESC) pluripotency. It is also known as E-616452 or SJN 2511. RepSox was first discovered in a screen for compounds that could replace Sox2, a transcription factor necessary for maintaining ESC pluripotency.
Mechanism of Action[edit | edit source]
RepSox acts by inhibiting the transforming growth factor beta (TGF-β) pathway. Specifically, it inhibits the ALK5 receptor, a type I receptor of the TGF-β pathway. This inhibition leads to the suppression of Smad2/Smad3 phosphorylation, which in turn promotes the expression of Nanog, a key transcription factor in maintaining ESC pluripotency.
Applications in Regenerative Medicine[edit | edit source]
The ability of RepSox to induce pluripotency has significant implications for regenerative medicine. It can be used to reprogram somatic cells into induced pluripotent stem cells (iPSCs) without the need for genetic manipulation. This is particularly useful in the generation of patient-specific iPSCs for disease modeling and cell therapy.
Safety and Toxicity[edit | edit source]
While RepSox has shown promise in preclinical studies, its safety and toxicity profile in humans is not yet fully understood. Further studies are needed to evaluate the potential risks associated with its use.
See Also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
