Retinoid X receptor beta

Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2), is a protein that in humans is encoded by the RXRB gene. RXR-beta forms heterodimers with retinoic acid receptors (RARs) and other nuclear receptors, such as thyroid hormone receptor, vitamin D receptor, and peroxisome proliferator-activated receptors (PPARs).

Function

RXR-beta is a member of the nuclear receptor family of transcription factors. It is involved in mediating the effects of retinoic acid, a metabolite of vitamin A, on gene expression. When bound to its ligand, RXR-beta forms a heterodimer with other nuclear receptors and binds to hormone response elements in DNA, leading to the transcription of specific genes.

Structure

The RXR-beta protein consists of several domains, including a DNA-binding domain and a ligand-binding domain. The DNA-binding domain recognizes and binds to specific sequences of DNA, while the ligand-binding domain binds to the receptor's specific ligand, retinoic acid.

Clinical significance

Alterations in the function of RXR-beta have been implicated in several diseases, including cancer, diabetes, and cardiovascular disease. For example, in certain types of cancer, the expression of RXR-beta is often downregulated, which may contribute to the development and progression of the disease.

See also

• Retinoid X receptor
• Retinoic acid receptor
• Nuclear receptor

External links

• GeneCards - RXRB: Retinoid X Receptor Beta