Riluzole

Information about Riluzole

Riluzole is a neuroprotective agent used for therapy of amyotrophic lateral sclerosis.

Liver safety of Riluzole

Riluzole is associated with a low rate of serum aminotransferase elevations during therapy and has been linked to rare instances of clinically apparent, acute liver injury.

Mechanism of action of Riluzole

Riluzole (ril' ue zole) is a benzothiazole that is neuroprotective in vitro and in vivo. The mechanism by which it protects neurons from toxic injury is unknown, but it appears to inhibit glutamate release, to block post-synaptic glutamate receptors and to inactivate voltage dependent sodium channels. Studies in patients with amyotrophic lateral sclerosis suggest that riluzole may slow disease progression and neurologic deterioration.

FDA approval information for Riluzole

Riluzole was approved for use in the United States in 1995 and is commonly used in management of amyotrophic lateral sclerosis.

Dosage and administration for Riluzole

Riluzole is available in tablets of 50 mg under the brand name Rilutek. The typical maintenance dosage is 50 mg every 12 hours. Common side effects include fatigue, weakness, dizziness, nausea, diarrhea, and cough.

The agents used to treat Alzheimer disease include:

• Donepezil
• Galantamine
• Memantine
• Riluzole
• Rivastigmine
• Tacrine

• Dailymed label info on Riluzole
• FDA Riluzole

Riluzole Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski