S1PR2

S1PR2 or Sphingosine-1-phosphate receptor 2 is a protein encoded by the S1PR2 gene in humans. It is a member of the G protein-coupled receptor family, which plays a crucial role in various biological processes.

Function

S1PR2 is a receptor for the bioactive lipid sphingosine 1-phosphate (S1P). S1P is a circulating lipid mediator that regulates a multitude of physiological processes, including angiogenesis, vasculogenesis, lymphocyte trafficking, heart rate, and endothelial cell and smooth muscle cell proliferation.

Clinical Significance

Alterations in S1PR2 function have been implicated in a variety of diseases, including cancer, inflammation, and autoimmune diseases. For example, overexpression of S1PR2 has been observed in glioblastoma, a type of brain cancer, and is associated with poor prognosis. In contrast, reduced S1PR2 expression has been linked to rheumatoid arthritis and multiple sclerosis.

Therapeutic Potential

Given its involvement in various disease processes, S1PR2 is considered a potential therapeutic target. Several S1PR2 antagonists are currently under investigation for their potential to treat conditions such as cancer, inflammation, and autoimmune diseases.

See Also

• Sphingosine-1-phosphate receptor
• G protein-coupled receptor
• Sphingosine 1-phosphate