S1PR2
S1PR2 or Sphingosine-1-phosphate receptor 2 is a protein encoded by the S1PR2 gene in humans. It is a member of the G protein-coupled receptor family, which plays a crucial role in various biological processes.
Function[edit | edit source]
S1PR2 is a receptor for the bioactive lipid sphingosine 1-phosphate (S1P). S1P is a circulating lipid mediator that regulates a multitude of physiological processes, including angiogenesis, vasculogenesis, lymphocyte trafficking, heart rate, and endothelial cell and smooth muscle cell proliferation.
Clinical Significance[edit | edit source]
Alterations in S1PR2 function have been implicated in a variety of diseases, including cancer, inflammation, and autoimmune diseases. For example, overexpression of S1PR2 has been observed in glioblastoma, a type of brain cancer, and is associated with poor prognosis. In contrast, reduced S1PR2 expression has been linked to rheumatoid arthritis and multiple sclerosis.
Therapeutic Potential[edit | edit source]
Given its involvement in various disease processes, S1PR2 is considered a potential therapeutic target. Several S1PR2 antagonists are currently under investigation for their potential to treat conditions such as cancer, inflammation, and autoimmune diseases.
See Also[edit | edit source]
References[edit | edit source]
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