SB-200646
SB-200646 is a chemical compound that acts as a selective antagonist for the 5-HT2B receptor. It is primarily used in scientific research to study the role of the 5-HT2B receptor in various physiological and pathological processes.
Pharmacology[edit | edit source]
SB-200646 is known for its high affinity and selectivity towards the 5-HT2B receptor, which is a subtype of the serotonin receptor. The compound has been instrumental in elucidating the functions of the 5-HT2B receptor, particularly in the cardiovascular system and central nervous system.
Mechanism of Action[edit | edit source]
As a 5-HT2B receptor antagonist, SB-200646 binds to the receptor and inhibits its activation by endogenous serotonin. This blockade can help researchers understand the receptor's role in various biological processes, including vasoconstriction, neurotransmission, and cell proliferation.
Research Applications[edit | edit source]
SB-200646 has been used in numerous studies to investigate the involvement of the 5-HT2B receptor in conditions such as pulmonary hypertension, cardiac fibrosis, and migraine. Its ability to selectively block the 5-HT2B receptor makes it a valuable tool for dissecting the receptor's specific contributions to these and other conditions.
Safety and Toxicology[edit | edit source]
While SB-200646 is primarily used in a research context, its safety profile has been evaluated in various preclinical studies. The compound is generally well-tolerated at doses used in research, but detailed toxicological data are limited.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
-
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
