SB-200646

SB-200646.svg

SB-200646 is a chemical compound that acts as a selective antagonist for the 5-HT2B receptor. It is primarily used in scientific research to study the role of the 5-HT2B receptor in various physiological and pathological processes.

Pharmacology

SB-200646 is known for its high affinity and selectivity towards the 5-HT2B receptor, which is a subtype of the serotonin receptor. The compound has been instrumental in elucidating the functions of the 5-HT2B receptor, particularly in the cardiovascular system and central nervous system.

Mechanism of Action

As a 5-HT2B receptor antagonist, SB-200646 binds to the receptor and inhibits its activation by endogenous serotonin. This blockade can help researchers understand the receptor's role in various biological processes, including vasoconstriction, neurotransmission, and cell proliferation.

Research Applications

SB-200646 has been used in numerous studies to investigate the involvement of the 5-HT2B receptor in conditions such as pulmonary hypertension, cardiac fibrosis, and migraine. Its ability to selectively block the 5-HT2B receptor makes it a valuable tool for dissecting the receptor's specific contributions to these and other conditions.

Safety and Toxicology

While SB-200646 is primarily used in a research context, its safety profile has been evaluated in various preclinical studies. The compound is generally well-tolerated at doses used in research, but detailed toxicological data are limited.

See Also

• 5-HT2 receptor
• Serotonin
• Receptor antagonist
• Pharmacology

External Links

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