SB-431542

SB-431542 is a potent and specific inhibitor of Transforming Growth Factor-beta (TGF-beta) superfamily type I Activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. It is used in scientific research to understand the role of TGF-beta in cellular processes.

Mechanism of Action

SB-431542 inhibits ALK4, ALK5, and ALK7 by binding to the ATP-binding pocket of these receptors, preventing the phosphorylation and activation of Smad proteins. This inhibition blocks the signal transduction of the TGF-beta superfamily, which is involved in a variety of cellular processes including cell proliferation, cell differentiation, apoptosis, and extracellular matrix production.

Uses in Research

SB-431542 is widely used in scientific research to study the role of TGF-beta in various cellular processes. It has been used to investigate the role of TGF-beta in cancer, fibrosis, wound healing, and embryonic development. It has also been used to enhance the efficiency of induced pluripotent stem cell (iPSC) generation from somatic cells by suppressing TGF-beta/Smad signaling.

References

SB-431542 Resources
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