SIRT2
| Identifiers | |
|---|---|
| EC number | 3.5.1.98 |
| CAS number | |
| Alt. names | |
| IntEnz | IntEnz view |
| BRENDA | BRENDA entry |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
Sirtuin 2 (SIRT2) is an enzyme that in humans is encoded by the SIRT2 gene. It is a member of the sirtuin family of proteins, which are characterized by their role in cellular regulation, particularly in response to DNA damage and oxidative stress. SIRT2 is primarily involved in the regulation of glucose metabolism, aging, and cellular stress responses.
Function[edit | edit source]
SIRT2 is a NAD+-dependent deacetylase, which primarily targets histones and several other proteins for deacetylation. This activity is crucial for the maintenance of chromatin structure and thus plays a significant role in gene expression regulation and cell cycle progression. SIRT2 has been shown to deacetylate tubulin, which is important for maintaining cytoskeleton integrity and cell division.
In addition to its role in chromatin remodeling and cytoskeletal organization, SIRT2 also influences lipid metabolism and insulin signaling, making it a key player in metabolic regulation. Its involvement in these processes makes it a potential target for the treatment of metabolic diseases such as diabetes and obesity.
Clinical Significance[edit | edit source]
Alterations in SIRT2 levels and activity have been associated with various diseases, including neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. SIRT2 inhibitors are being studied for their potential to treat these conditions by preserving neuronal health and function.
Furthermore, SIRT2 has been implicated in the aging process. Modulation of SIRT2 activity has been suggested as a possible intervention to delay aging and extend lifespan.
Research[edit | edit source]
Research on SIRT2 continues to uncover its various roles in cellular processes and disease mechanisms. Studies are exploring its potential as a therapeutic target for age-related diseases, metabolic disorders, and even certain types of cancer.
See Also[edit | edit source]
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