SLC22A9

SLC22A9 is a gene that encodes a member of the solute carrier family 22 (SLC22), which is involved in the transport of organic ions across cell membranes. This family of transporters plays a crucial role in the pharmacokinetics of drugs and the excretion of endogenous compounds.

Function

The SLC22A9 gene product is an organic anion transporter, which is primarily expressed in the liver and kidney. It is responsible for the uptake and excretion of a wide range of organic anions, including drugs, metabolites, and toxins. This transporter is important for the detoxification processes in the body and influences the bioavailability and clearance of various pharmacological agents.

Clinical Significance

Mutations or variations in the SLC22A9 gene can affect drug response and toxicity. Understanding the function and regulation of this transporter can aid in the development of personalized medicine approaches, particularly in optimizing drug dosing and minimizing adverse drug reactions. Research into SLC22A9 may also provide insights into disease mechanisms where altered transport of organic anions is implicated.

Research

Studies on SLC22A9 involve investigating its substrate specificity, regulatory mechanisms, and its role in drug-drug interactions. Researchers use various biochemical and molecular biology techniques to elucidate the structure-function relationship of this transporter.

See Also

• Solute carrier family
• Organic anion transporter
• Pharmacogenomics

External Links

• SLC22A9 Gene - NCBI
• SLC22A9 Gene - GeneCards