STAT6

STAT6 (Signal Transducer and Activator of Transcription 6) is a protein that in humans is encoded by the STAT6 gene. It is a member of the STAT protein family and plays a central role in exerting Interleukin 4 mediated biological responses.

Function

STAT6 is critically involved in the body's immune response. It is activated by Interleukin 4 and Interleukin 13, and is required for their function in Th2 cell differentiation and inflammatory responses. The protein is found in the cytoplasm and is activated by cytokine receptor-associated kinases. Once activated, it dimerizes and translocates to the nucleus where it exerts its transcriptional regulatory functions.

Clinical significance

Mutations in the STAT6 gene have been associated with hyper IgE syndrome (HIES) and allergic diseases. The protein is also involved in the development of T helper cells, which play a key role in the immune response to pathogens. In addition, STAT6 has been implicated in the pathogenesis of several types of cancer, including breast cancer and prostate cancer.

Interactions

STAT6 has been shown to interact with a number of other proteins, including NCOA1, STAT1, and STAT3. These interactions are important for the protein's function in immune response and cell growth.

See also

• STAT protein
• Interleukin 4
• Interleukin 13
• T helper cell
• Cytokine

External links

• STAT6 at NCBI
• STAT6 at UniProt