STAT1
STAT1 (Signal Transducer and Activator of Transcription 1) is a protein that in humans is encoded by the STAT1 gene. It is a member of the STAT protein family and plays a crucial role in upregulating genes in response to cellular stimulation by interferon-gamma and other cytokines.
Function[edit | edit source]
STAT1 is involved in upregulating genes due to a signal by interferon-gamma. Interferon-gamma binds to its receptor, which triggers a signaling cascade that leads to the activation of STAT1. Once activated, STAT1 can move into the nucleus of the cell and bind to DNA, which stimulates the transcription of genes.
Clinical significance[edit | edit source]
Mutations in the STAT1 gene can lead to immunodeficiency with increased susceptibility to certain pathogens, such as mycobacteria. This condition is known as Mendelian susceptibility to mycobacterial disease (MSMD). Additionally, STAT1 is involved in the development and function of the immune system and plays a role in the development of cancer.
Interactions[edit | edit source]
STAT1 has been shown to interact with a variety of proteins, including IRF1, STAT2, NMI and others.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- STAT1 at the US National Library of Medicine Medical Subject Headings (MeSH)
| STAT1 Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
