STAT2
STAT2 (Signal Transducer and Activator of Transcription 2) is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family and plays a crucial role in cellular responses to interferon type I.
Function[edit | edit source]
STAT2 protein is a transcriptional activator that is vital for the cellular responses to interferon type I (IFN-alpha and IFN-beta). After the binding of type I interferons to receptors, the JAK kinase family is activated, leading to the phosphorylation of STAT1 and STAT2. The phosphorylated STATs then form a complex with IRF9 to create the ISGF3 transcription factor, which binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes.
Clinical significance[edit | edit source]
Mutations in the STAT2 gene have been associated with susceptibility to mycobacterial and viral infections. In addition, STAT2 has been identified as a key player in the antiviral responses of cells, particularly in the context of Hepatitis C and Zika virus infections.
Interactions[edit | edit source]
STAT2 has been shown to interact with:
References[edit | edit source]
External links[edit | edit source]
- STAT2 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
