Salicyluric acid

Salicyluric acid is a metabolite of salicylic acid, a compound commonly found in medications such as aspirin. It is formed in the body through the process of hydroxylation of salicylic acid. Salicyluric acid is excreted in the urine and is considered a major urinary metabolite of salicylic acid.

Chemical Structure

Salicyluric acid has a chemical structure similar to that of salicylic acid, with an additional hydroxyl group attached to the benzene ring. Its chemical formula is C7H6O4.

Metabolism

Salicyluric acid is formed in the liver through the action of enzymes that hydroxylate salicylic acid. This metabolic pathway is important for the elimination of salicylic acid from the body.

Biological Activity

Salicyluric acid is considered to be pharmacologically inactive. It is primarily a byproduct of the metabolism of salicylic acid and does not exhibit significant biological activity on its own.

Clinical Significance

Measurement of salicyluric acid levels in urine can be used as a marker of salicylic acid exposure. High levels of salicyluric acid may indicate overdose or chronic use of salicylic acid-containing medications.

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