Serostim

Serostim is a brand name for somatropin, a form of human growth hormone produced by recombinant DNA technology. It is primarily used for the treatment of HIV-associated wasting or cachexia, characterized by profound involuntary weight loss and muscle atrophy. Serostim is manufactured by Merck Serono, a division of the German pharmaceutical company, Merck KGaA.

Medical uses

Serostim is indicated for the treatment of HIV-associated wasting. The therapy aims to improve physical endurance, increase lean body mass, and enhance weight gain. It is prescribed to patients who have experienced significant weight loss as a result of their HIV infection, particularly those who have not responded to conventional antiretroviral therapy alone.

Mechanism of action

Serostim functions by mimicking the natural growth hormone that is produced by the pituitary gland. Growth hormone plays a crucial role in metabolism, body composition, and muscle growth. In patients with HIV-associated wasting, the administration of Serostim helps to increase muscle mass and improve physical stamina by stimulating protein synthesis and energy production.

Administration

Serostim is administered through subcutaneous injections. The dosage and duration of treatment depend on the patient's body weight and clinical response to the therapy. It is important that the treatment is monitored by a healthcare professional to adjust dosages as necessary and to manage any potential side effects.

Side effects

The use of Serostim can lead to several side effects, including but not limited to:

• Edema (swelling due to fluid retention)
• Carpal tunnel syndrome
• Increased blood glucose levels
• Joint and muscle pain
• Gynecomastia (enlargement of breast tissue in men)

Patients are advised to report any adverse effects to their healthcare provider, who may adjust the treatment regimen accordingly.

Regulatory status

Serostim has been approved by the Food and Drug Administration (FDA) in the United States for the treatment of HIV-associated wasting. It is also regulated and approved for use in several other countries, subject to the guidelines and approval of local health authorities.

See also

• Growth hormone treatment
• HIV/AIDS
• Wasting syndrome