Single transverse palmar crease

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Single Transverse Palmar Crease[edit | edit source]

The Single Transverse Palmar Crease (STPC), also known as a simian crease, is a unique feature where the two major palmar creases (the heart line and head line) are fused into a single line that runs across the palm. Traditionally, this feature is observed in both palms of approximately 1% of the general population but is more commonly unilateral. The presence of an STPC can be a normal variant; however, it is also associated with certain medical conditions and syndromes.

Overview[edit | edit source]

A single transverse palmar crease is formed during fetal development, typically by the 12th week of gestation. The crease is made visible by the underlying flexor tendons. In most individuals, the palm has three distinct lines: the heart line, head line, and life line. The STPC occurs when the first two merge into one.

A hand displaying a Single Transverse Palmar Crease. (Placeholder image)

Clinical Significance[edit | edit source]

While an STPC can appear in healthy individuals with no other symptoms, its presence is notably higher in certain chromosomal and genetic disorders, making it a point of clinical interest:

Associated Conditions[edit | edit source]

  • Down Syndrome: The most well-known association of STPC is with Down syndrome, where it is present in 45% of individuals.
  • Turner Syndrome: A condition affecting females, where one of the X chromosomes is missing or partially missing.
  • Noonan Syndrome: A genetic disorder that prevents normal development in various parts of the body.
  • Klinefelter Syndrome: A genetic condition affecting males, characterized by an extra X chromosome.

Implications[edit | edit source]

The presence of a Single Transverse Palmar Crease alone is not diagnostic of any condition, but it can be one of several indicators that suggest further genetic evaluation is warranted, especially if other symptoms or anomalies are present.

Diagnosis and Evaluation[edit | edit source]

The identification of an STPC is typically made through physical examination. When a single palmar crease is observed, particularly if it is bilateral, healthcare providers may recommend genetic testing or further evaluation to rule out associated syndromes, especially if additional physical or developmental anomalies are noted.

Genetic Counseling[edit | edit source]

For individuals or families where an STPC is identified, especially in the context of a diagnosed condition, genetic counseling may be offered. Counseling provides information on the inheritance patterns, risks to other family members, and implications for future pregnancies.

External Links[edit | edit source]


Single transverse palmar crease Resources

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