Sjogren's syndrome

From WikiMD's Wellnesspedia

Sjögren's syndrome is a long-term autoimmune disease that primarily affects the body's moisture-producing glands, leading to significant dryness in the eyes and mouth. This condition can also affect other parts of the body, including the skin, joints, lungs, kidneys, and nervous system. It is named after the Swedish ophthalmologist Henrik Sjögren, who first described it in the early 20th century.

Etiology and Pathogenesis[edit | edit source]

The exact cause of Sjögren's syndrome is unknown, but it is believed to be a combination of genetic, environmental, and possibly viral factors that trigger an autoimmune response. In people with Sjögren's syndrome, the immune system mistakenly attacks the body's own cells and tissues, specifically targeting the exocrine glands that produce tears and saliva. This results in decreased production of saliva and tears, leading to the hallmark symptoms of dry mouth (Xerostomia) and dry eyes (Keratoconjunctivitis sicca).

Symptoms[edit | edit source]

The primary symptoms of Sjögren's syndrome are:

  • Dry eyes, which can feel gritty or burn
  • Dry mouth, making it difficult to swallow or speak
  • Fatigue
  • Joint pain, swelling, and stiffness

Other symptoms may include dry skin, vaginal dryness, persistent dry cough, and prolonged fatigue. Sjögren's can also lead to more serious complications, such as dental cavities due to reduced saliva, or organ involvement like hepatitis, interstitial cystitis, and pancreatitis.

Diagnosis[edit | edit source]

Diagnosis of Sjögren's syndrome can be challenging due to the overlap of symptoms with other conditions. It typically involves a combination of patient history, physical examination, blood tests for specific antibodies (such as anti-SSA/Ro and anti-SSB/La), and imaging tests. Biopsy of the salivary glands may also be performed to look for signs of autoimmune damage.

Treatment[edit | edit source]

There is no cure for Sjögren's syndrome, but treatment focuses on relieving symptoms and preventing complications. This may include:

  • Artificial tears and saliva substitutes
  • Medications to stimulate saliva production, such as pilocarpine and cevimeline
  • Immunosuppressive drugs for systemic involvement
  • Good oral hygiene and regular dental visits to prevent cavities and oral infections

Lifestyle modifications, such as staying hydrated, using a humidifier, and avoiding medications that can worsen dryness, are also important.

Prognosis[edit | edit source]

The prognosis for individuals with Sjögren's syndrome varies. While the condition itself is not life-threatening, it can significantly affect quality of life and lead to complications if not properly managed. Early diagnosis and treatment are crucial to prevent or minimize damage to the glands and other organs.

Epidemiology[edit | edit source]

Sjögren's syndrome affects millions of people worldwide, with a higher prevalence in women than in men. It typically presents in the fourth or fifth decade of life, but can occur at any age.

Resources[edit source]

Latest articles - Sjogren's syndrome

PubMed
Clinical trials
UpToDate

AI tools[edit source]

Generative AI tools and links to learn more on Sjogren's syndrome: ChatGPT - Bing Chat - Google Gemini. (caution advised).


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