Sneddon-Wilkinson disease
Sneddon-Wilkinson Disease[edit | edit source]
Sneddon-Wilkinson disease, also known as subcorneal pustular dermatosis, is a rare chronic skin condition characterized by the recurrent appearance of pustules on the skin. It was first described by Sneddon and Wilkinson in 1956.
Clinical Presentation[edit | edit source]
Patients with Sneddon-Wilkinson disease typically present with flaccid pustules that are superficial and filled with neutrophils. These pustules often appear on the trunk, intertriginous areas, and flexural surfaces. The pustules may coalesce to form annular or serpiginous patterns. The condition is usually chronic and relapsing.
Pathophysiology[edit | edit source]
The exact cause of Sneddon-Wilkinson disease is unknown, but it is thought to be related to an abnormal immune response. Histologically, the disease is characterized by subcorneal pustules filled with neutrophils, which is a hallmark of the condition.
Diagnosis[edit | edit source]
Diagnosis of Sneddon-Wilkinson disease is primarily clinical, supported by histopathological examination. A skin biopsy will typically show subcorneal pustules with neutrophilic infiltration. Direct immunofluorescence is usually negative, which helps differentiate it from other blistering diseases.
Differential Diagnosis[edit | edit source]
Sneddon-Wilkinson disease should be differentiated from other pustular dermatoses such as:
Treatment[edit | edit source]
The mainstay of treatment for Sneddon-Wilkinson disease is dapsone, which is effective in controlling the pustular eruptions. Other treatments that may be used include:
Prognosis[edit | edit source]
The prognosis for Sneddon-Wilkinson disease is generally good with appropriate treatment. However, the condition is chronic and may require long-term management to prevent relapses.
Epidemiology[edit | edit source]
Sneddon-Wilkinson disease is a rare condition, with a higher prevalence in middle-aged women. The exact incidence and prevalence are not well-documented due to its rarity.
See Also[edit | edit source]
NIH genetic and rare disease info[edit source]
Sneddon-Wilkinson disease is a rare disease.
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