Somatostatin receptor 1

Somatostatin receptor 1 (SSTR1) is a protein that in humans is encoded by the SSTR1 gene. It is one of the five somatostatin receptors.

Function

Somatostatin receptor 1 is a G protein-coupled receptor that is expressed in the pancreas, kidney, and central nervous system. It binds somatostatin, a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors.

Clinical significance

Alterations in somatostatin receptor 1 function have been associated with various diseases, including neuroendocrine tumors, Alzheimer's disease, and schizophrenia. In neuroendocrine tumors, somatostatin analogs can be used to target the somatostatin receptor 1 for diagnostic and therapeutic purposes.

See also

• Somatostatin receptor
• G protein-coupled receptor
• Neuroendocrine tumor
• Alzheimer's disease
• Schizophrenia

External links

• SSTR1 at HGNC
• SSTR1 at UniProt

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