Somatostatin receptor 1
Somatostatin receptor 1 (SSTR1) is a protein that in humans is encoded by the SSTR1 gene. It is one of the five somatostatin receptors.
Function[edit | edit source]
Somatostatin receptor 1 is a G protein-coupled receptor that is expressed in the pancreas, kidney, and central nervous system. It binds somatostatin, a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors.
Clinical significance[edit | edit source]
Alterations in somatostatin receptor 1 function have been associated with various diseases, including neuroendocrine tumors, Alzheimer's disease, and schizophrenia. In neuroendocrine tumors, somatostatin analogs can be used to target the somatostatin receptor 1 for diagnostic and therapeutic purposes.
See also[edit | edit source]
- Somatostatin receptor
- G protein-coupled receptor
- Neuroendocrine tumor
- Alzheimer's disease
- Schizophrenia
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
