Spiroxasone
A synthetic steroidal antimineralocorticoid and antiandrogen
| Spiroxasone | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Spiroxasone is a synthetic steroidal antimineralocorticoid and antiandrogen that was developed for the treatment of conditions such as hypertension and heart failure. It is a derivative of spironolactone, a well-known potassium-sparing diuretic.
Pharmacology[edit | edit source]
Mechanism of Action[edit | edit source]
Spiroxasone acts as an antagonist of the mineralocorticoid receptor, which is responsible for the effects of aldosterone in the body. By blocking this receptor, spiroxasone reduces sodium reabsorption and increases potassium retention, leading to a diuretic effect. Additionally, it has antiandrogenic properties, which means it can block the effects of androgens like testosterone.
Pharmacokinetics[edit | edit source]
The pharmacokinetic profile of spiroxasone includes its absorption, distribution, metabolism, and excretion. Like other steroidal antimineralocorticoids, it is metabolized in the liver and excreted primarily in the urine.
Clinical Use[edit | edit source]
Spiroxasone was investigated for use in conditions such as hypertension, heart failure, and hirsutism. However, it was never marketed, and its clinical use remains limited to research settings.
Side Effects[edit | edit source]
Potential side effects of spiroxasone include hyperkalemia, gynecomastia, and menstrual irregularities. These are similar to those observed with other antimineralocorticoids and antiandrogens.
Chemical Structure[edit | edit source]
Spiroxasone is a synthetic steroid with a chemical structure similar to that of spironolactone. It contains a lactone ring and a thioacetate group, which are characteristic of this class of compounds.
Related Compounds[edit | edit source]
Spiroxasone is related to other antimineralocorticoids such as spironolactone and eplerenone. These compounds share similar mechanisms of action and therapeutic uses.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
