Eplerenone

Eplerenone

Eplerenone is a steroidal antimineralocorticoid of the spirolactone group that is used as an adjunct in the management of chronic heart failure. Classified as a selective aldosterone receptor antagonist (SARA), it is similar to the diuretic spironolactone, though it is much more selective for the mineralocorticoid receptor in comparison (i.e., does not possess any antiandrogen, glucocorticoid, or progesterone receptor activity), and is specifically marketed for reducing cardiovascular risk in patients following a myocardial infarction. Eplerenone is a potassium-sparing diuretic, meaning that it helps the body get rid of water but not potassium. It is available under the brand name Inspra.

Pharmacology

Eplerenone selectively binds to the mineralocorticoid receptor and blocks the binding of aldosterone, a hormone that regulates the balance of water and electrolytes in the body. Aldosterone binding to mineralocorticoid receptors can cause high blood pressure and heart failure. By blocking the effect of aldosterone, eplerenone reduces the amount of sodium and water the body retains and helps to lower blood pressure.

Clinical use

Eplerenone is used for the treatment of congestive heart failure following a heart attack and also to treat high blood pressure. It is usually prescribed along with other medications. Eplerenone has been shown to reduce the risk of cardiovascular death in elderly patients after a heart attack.

Side effects

Common side effects of eplerenone include headache, dizziness, stomach pain, and fatigue. Serious side effects may include high potassium levels, irregular heartbeat, and severe allergic reactions.

See also

• Spironolactone
• Mineralocorticoid receptor
• Heart failure

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