Sternberg cell

Sternberg Cell

The Sternberg cell is a type of cell that is primarily associated with Hodgkin's lymphoma, a type of cancer that originates from white blood cells. Named after the German pathologist Karl Sternberg, these cells are a defining characteristic of the disease and play a crucial role in its diagnosis.

History

The Sternberg cell was first identified by Karl Sternberg in the late 19th century. Sternberg was a German pathologist who made significant contributions to the field of hematology, the study of blood and blood diseases. His discovery of the Sternberg cell has since become a cornerstone in the diagnosis of Hodgkin's lymphoma.

Characteristics

Sternberg cells are large, atypical cells that are characterized by their distinctive morphology. They typically have a large, irregular nucleus with a prominent nucleolus and an abundant, clear cytoplasm. The presence of these cells in a biopsy sample is often indicative of Hodgkin's lymphoma.

Role in Hodgkin's Lymphoma

In the context of Hodgkin's lymphoma, Sternberg cells are often found in the lymph nodes. They are believed to be derived from B cells, a type of white blood cell, and their presence is a key factor in the diagnosis of the disease. However, the exact role of Sternberg cells in the pathogenesis of Hodgkin's lymphoma is still not fully understood and is the subject of ongoing research.

Diagnosis

The diagnosis of Hodgkin's lymphoma often involves the identification of Sternberg cells in a biopsy sample. This is typically done through histopathology, a method that involves the examination of tissues under a microscope. The presence of Sternberg cells, along with other clinical and laboratory findings, can help confirm the diagnosis of the disease.

See Also

• Hodgkin's lymphoma
• Cell (biology)
• Karl Sternberg
• Histopathology