Synaptopodin

Synaptopodin is a protein that in humans is encoded by the SYNPO gene. It is an actin-associated protein that plays a vital role in regulating the morphology and function of the kidney's podocytes.

Function

Synaptopodin is an actin-associated protein that may play a key role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (foot processes). In the nervous system, synaptopodin is involved in the regulation of spine morphology and synaptic plasticity. In the kidney, it is involved in the maintenance of foot process structure and filtration barrier function.

Clinical significance

Mutations in the SYNPO gene have been associated with focal segmental glomerulosclerosis, a kidney disease characterized by proteinuria and progression to end-stage kidney disease.

Structure

Synaptopodin is a 738-amino acid protein with a calculated molecular mass of 75 kDa. It is characterized by the presence of a proline-rich domain and a coiled-coil domain.

Expression

Synaptopodin is expressed in highly dynamic cell compartments such as the leading lamellipodia of migrating cells, the tips of stress fibers in spreading cells, and the podosomal/adhesive belts of spreading cells.

See also

• Podocyte
• Actin
• Focal segmental glomerulosclerosis

References

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian