Synovial membrane

Synovial membrane or synovium is a specialized connective tissue that lines the inner surface of capsules of synovial joints and tendon sheath. It makes direct contact with the synovial fluid lubricant, which it is primarily responsible for maintaining. In contact with the synovial fluid at the tissue surface are many rounded macrophage-like synovial cells and type B synovial cells.

Structure

The synovial membrane is a thin, smooth layer of connective tissue that lines the surfaces of the joint capsule and secretes synovial fluid. It is primarily made up of two types of cells, but is also contains fat cells and is surrounded by a network of blood vessels and lymphatic vessels.

Cells

The synovial membrane is primarily made up of two types of cells. These are type A synovial cells and type B synovial cells. Type A synovial cells are similar to macrophages and are responsible for the removal of wear-and-tear debris from the synovial fluid. Type B synovial cells are responsible for the secretion of hyaluronan and lubricin, the two main components of the synovial fluid.

Function

The synovial membrane's main function is to produce and maintain the synovial fluid, a thick, clear liquid that lubricates the joints and allows for smooth movement. The synovial fluid also provides nutrients to the avascular articular cartilage and removes waste products from the joint capsule.

Clinical significance

Diseases and conditions that affect the synovial membrane can lead to joint pain and loss of function. These include rheumatoid arthritis, osteoarthritis, gout, and lupus. In these conditions, the synovial membrane becomes inflamed and thickened, leading to an overproduction of synovial fluid and causing pain and swelling in the joint.

See also

• Synovial fluid
• Synovial joint
• Joint capsule

References

Synovial membrane Resources
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