TAG-72 antigen
TAG-72 antigen is a tumor-associated antigen that is expressed in a variety of human cancers, including ovarian cancer, breast cancer, colon cancer, and pancreatic cancer. It is a high molecular weight, mucin-like glycoprotein that is found on the surface of cancer cells and in the serum of patients with cancer. The antigen is used as a marker for the detection and monitoring of cancer.
Structure[edit | edit source]
TAG-72 antigen is a glycoprotein with a high molecular weight. It is a mucin-like protein, which means it has a high content of carbohydrates and is heavily glycosylated. The protein is composed of repeating units of a 20 amino acid sequence.
Expression in cancer[edit | edit source]
TAG-72 antigen is expressed in a variety of human cancers. It is found on the surface of cancer cells and in the serum of patients with cancer. The antigen is used as a marker for the detection and monitoring of cancer. It is particularly useful in the detection of ovarian cancer, breast cancer, colon cancer, and pancreatic cancer.
Clinical significance[edit | edit source]
The presence of TAG-72 antigen in the serum of patients with cancer can be used as a marker for the detection and monitoring of the disease. It can also be used to monitor the response to treatment. In addition, the antigen can be targeted for therapy, for example, by using monoclonal antibodies that bind to the antigen and deliver a toxic payload to the cancer cells.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
