Tumor-associated glycoprotein 72

Tumor-associated glycoprotein 72 (TAG-72) is a glycoprotein found on the surface of many cancer cells, including ovary, breast, colon, lung, and pancreatic cancers.

TAG-72 is a tumor marker measured with radioimmunoassays like CA 72-4, which uses the monoclonal antibodies indium (¹¹¹In) satumomab pendetide and iodine (¹²⁵I) minretumomab.

TAG-72 is also the target of the anti-cancer drugs anatumomab mafenatox and minretumomab.

References

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".