TAS2R3

TAS2R3

TAS2R3 is a gene that encodes a protein known as the bitter taste receptor, type 2, member 3. This protein is a part of the taste receptor family, specifically the bitter taste receptors. These receptors are responsible for the perception of bitter taste in humans and other animals.

Function

The TAS2R3 protein is expressed in the taste buds on the tongue, where it binds to bitter compounds in food. When these compounds bind to the receptor, a signal is sent to the brain, resulting in the perception of a bitter taste. This mechanism helps to protect against the ingestion of potentially harmful substances, many of which have a bitter taste.

Genetic Variation

Variations in the TAS2R3 gene can affect an individual's sensitivity to bitter tastes. Some people have a version of the gene that makes them particularly sensitive to certain bitter compounds, while others have a version that makes them less sensitive. These differences can influence dietary choices and may have implications for health.

Clinical Significance

Research has suggested that variations in the TAS2R3 gene may be associated with certain health conditions. For example, some studies have found a link between TAS2R3 variations and an increased risk of obesity and type 2 diabetes. However, more research is needed to confirm these findings and understand the underlying mechanisms.

See Also

• Taste receptor
• Bitter taste receptors
• Taste buds
• Obesity
• Type 2 diabetes