TAS2R4

TAS2R4 is a gene that provides instructions for making a protein that is part of the bitter taste receptor family. This protein, known as the TAS2R4 receptor, is found on the surface of taste bud cells in the tongue. The TAS2R4 receptor is involved in the perception of bitter taste.

Function

The TAS2R4 receptor is a member of the TAS2R (taste receptor, type 2) protein family. These proteins are specialized to detect bitter compounds. When a bitter compound binds to the TAS2R4 receptor, it triggers a series of chemical reactions inside the taste bud cell. This process, known as signal transduction, leads to the perception of a bitter taste.

Genetic variation

Variations in the TAS2R4 gene can affect the function of the TAS2R4 receptor and influence an individual's sensitivity to certain bitter tastes. For example, some people may find certain foods or drinks to be more bitter than others due to differences in their TAS2R4 gene.

Clinical significance

Research suggests that the TAS2R4 receptor may play a role in certain health conditions. For example, some studies have found that people with variations in the TAS2R4 gene may have a higher risk of developing obesity or type 2 diabetes. However, more research is needed to confirm these findings and understand the potential role of TAS2R4 in these conditions.

See also

• Taste receptor
• TAS2R
• Taste bud
• Signal transduction