TGFBI

TGFBI (Transforming Growth Factor Beta Induced) is a protein that in humans is encoded by the TGFBI gene. This protein plays a crucial role in cell adhesion and cell migration, and is involved in various cellular processes such as apoptosis, cell proliferation, and cell differentiation.

Function

TGFBI protein is a secreted protein that binds to collagen, fibronectin, and laminin and plays a role in cell-collagen interactions. The protein is induced by transforming growth factor-beta (TGF-beta) and acts to inhibit cell adhesion and migration. It is also thought to play a role in the extracellular matrix and in the development of the cornea.

Clinical significance

Mutations in the TGFBI gene are associated with several corneal dystrophies, including granular corneal dystrophy type 1, lattice corneal dystrophy type 1, and Avellino corneal dystrophy. These conditions are characterized by the accumulation of abnormal TGFBI protein in the cornea, leading to vision loss.

Research

Research into TGFBI has focused on its role in cell adhesion and migration, as well as its potential role in cancer. Some studies suggest that TGFBI may act as a tumor suppressor gene, inhibiting the growth and spread of cancer cells.

See also

• Transforming growth factor beta
• Corneal dystrophy
• Cell adhesion
• Cell migration

References

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