TRPM2

TRPM2 (Transient Receptor Potential Melastatin 2) is a protein that in humans is encoded by the TRPM2 gene. It is a member of the transient receptor potential channel family, which are cation channels that play a role in a variety of physiological processes.

Function

TRPM2 is a non-selective cation channel that is activated by intracellular adenosine diphosphate ribose (ADPR) and by reactive oxygen species (ROS). It is permeable to calcium, sodium, and potassium ions. The channel is involved in several physiological processes, including cell death, insulin secretion, and neurotransmission.

Structure

The TRPM2 channel is a tetramer, with each subunit consisting of six transmembrane segments (S1-S6), a pore-forming loop between S5 and S6, and a large cytoplasmic N-terminal domain that contains a nucleotide-binding domain.

Clinical significance

Mutations in the TRPM2 gene have been associated with several diseases, including bipolar disorder, ischemic stroke, and neurodegenerative diseases. In addition, the channel has been implicated in the pathogenesis of inflammatory diseases and cancer.

Research

Research on TRPM2 has focused on its role in cell death and inflammation, as well as its potential as a therapeutic target for diseases such as cancer and neurodegenerative disorders.

See also

• Transient receptor potential channel
• Calcium channel
• Sodium channel
• Potassium channel