TRPM4

TRPM4 is a protein that in humans is encoded by the TRPM4 gene. It is a member of the transient receptor potential (TRP) channel family, which is a diverse group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. These channels are known to play a critical role in sensing environmental and cellular signals.

Function

TRPM4 is a calcium-activated non-selective cation channel that does not seem to be under the control of a phosphatidylinositol second messenger system. It is not permeable to calcium, and is activated by intracellular calcium. It is proposed to be involved in various biological processes including cell volume regulation, apoptosis, and insulin secretion.

Clinical significance

Mutations in the TRPM4 gene have been associated with progressive familial heart block type I (PFHBI), a rare disorder characterized by progressive degeneration of the cardiac conduction system. It has also been implicated in the development of certain types of cancer, including prostate cancer and breast cancer.

Structure

The TRPM4 channel is composed of four identical subunits, each containing six transmembrane segments. The channel is activated by increased intracellular calcium and is thought to be voltage-dependent.

See also

• Transient receptor potential channel
• Calcium-activated non-selective cation channel
• Progressive familial heart block

External links

• TRPM4 at GeneCards