Talopram
Talopram is a pharmaceutical drug that belongs to the class of selective serotonin reuptake inhibitors (SSRIs). It is primarily used in the treatment of depression and anxiety disorders. Talopram works by increasing the levels of serotonin in the brain, which helps improve mood and reduce symptoms of anxiety.
Mechanism of Action[edit | edit source]
Talopram functions by inhibiting the reuptake of serotonin, a neurotransmitter, into the presynaptic neuron. This inhibition increases the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission. The increased availability of serotonin in the brain is believed to contribute to its antidepressant and anxiolytic effects.
Indications[edit | edit source]
Talopram is indicated for the treatment of:
Side Effects[edit | edit source]
Common side effects of Talopram include:
Less common but more serious side effects may include:
Contraindications[edit | edit source]
Talopram is contraindicated in individuals with:
- Known hypersensitivity to Talopram or any of its components
- Concurrent use of monoamine oxidase inhibitors (MAOIs)
- Severe liver impairment
Dosage and Administration[edit | edit source]
Talopram is typically administered orally, with or without food. The dosage varies depending on the condition being treated and the patient's response to the medication. It is important to follow the prescribing physician's instructions carefully.
Pharmacokinetics[edit | edit source]
Talopram is well-absorbed from the gastrointestinal tract and reaches peak plasma concentrations within a few hours of administration. It is metabolized primarily in the liver and excreted through the kidneys. The half-life of Talopram is approximately 24 hours, allowing for once-daily dosing.
History[edit | edit source]
Talopram was developed in the late 20th century as part of the ongoing search for effective treatments for depression and anxiety. It was approved for medical use in several countries and has since become a widely prescribed medication for these conditions.
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References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD