Talopram

Talopram is a norepinephrine reuptake inhibitor that was developed in the 1960s by Eli Lilly but was never marketed. It is structurally related to desipramine and imipramine.

Chemistry

Talopram is a tricyclic antidepressant (TCA) that is structurally related to other TCAs such as desipramine and imipramine. It is a tertiary amine TCA, meaning it has three rings in its chemical structure.

Pharmacology

Talopram acts primarily as a norepinephrine reuptake inhibitor, meaning it increases the amount of norepinephrine in the brain by blocking its reuptake into neurons. This can lead to increased norepinephrine activity, which can have various effects on mood and cognition.

History

Talopram was developed in the 1960s by the pharmaceutical company Eli Lilly. Despite showing promise in early trials, it was never marketed for use in humans. The reasons for this are unclear, but may be related to the development of newer, more effective antidepressants.

See also

• Norepinephrine reuptake inhibitor
• Tricyclic antidepressant
• Eli Lilly

Talopram Resources
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