Testosterone hexyloxyphenylpropionate

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Testosterone hexyloxyphenylpropionate


Testosterone hexyloxyphenylpropionate is an androgen and anabolic steroid (AAS) and a testosterone ester. It is or has been marketed under the brand names Androxon, Panteston, and Restandol. Testosterone hexyloxyphenylpropionate is used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive.

Pharmacology[edit | edit source]

As an androgen and anabolic steroid, testosterone hexyloxyphenylpropionate has similar effects to other testosterone esters. It increases muscle mass, strength, and libido, and has effects on mood, energy levels, and fat distribution. It is a prodrug of testosterone and is converted into testosterone in the body.

Chemistry[edit | edit source]

Testosterone hexyloxyphenylpropionate, like all testosterone esters, is a prodrug of testosterone. It is an esterified variant of testosterone with a hexyloxyphenylpropionate ester attached to the testosterone molecule. This esterification makes the testosterone more soluble in oil, which allows for a slower release and longer half-life when injected.

History[edit | edit source]

Testosterone hexyloxyphenylpropionate was first described in the literature in 1970. It was developed by Organon International, a pharmaceutical company, and was marketed under the brand names Androxon, Panteston, and Restandol.

Society and culture[edit | edit source]

Testosterone hexyloxyphenylpropionate is a controlled substance in many countries and is classified as a Schedule III drug in the United States under the Controlled Substances Act. It is also on the World Anti-Doping Agency's list of prohibited substances, and is therefore banned from use in most professional sports.

See also[edit | edit source]

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Contributors: Prab R. Tumpati, MD