Testosterone undecanoate
Testosterone undecanoate is a synthetic androgen and anabolic steroid (AAS) used primarily in the treatment of male hypogonadism, a condition in which the body does not produce enough testosterone. It is an ester of testosterone and is administered via intramuscular injection or orally.
Medical Uses[edit | edit source]
Testosterone undecanoate is used in hormone replacement therapy (HRT) for men with low testosterone levels. It helps to restore normal levels of testosterone, which can improve symptoms such as low energy, reduced libido, and loss of muscle mass. It is also used in the treatment of delayed puberty in boys and certain types of breast cancer in women.
Pharmacology[edit | edit source]
Testosterone undecanoate is a prodrug of testosterone, meaning it is converted into active testosterone in the body. It has a long duration of action, which allows for less frequent dosing compared to other testosterone esters. When administered intramuscularly, it is typically given every 10 to 14 weeks. Oral formulations are also available, but they are less commonly used due to variable absorption and bioavailability.
Side Effects[edit | edit source]
Common side effects of testosterone undecanoate include acne, oily skin, and increased red blood cell count. More serious side effects can include cardiovascular disease, liver toxicity, and prostate cancer. It is important for patients to be monitored regularly by their healthcare provider while on this medication.
Contraindications[edit | edit source]
Testosterone undecanoate should not be used in individuals with prostate cancer, breast cancer, or severe heart disease. It is also contraindicated in women who are pregnant or breastfeeding.
Mechanism of Action[edit | edit source]
Testosterone undecanoate works by being hydrolyzed into testosterone in the body. Testosterone then binds to androgen receptors, which leads to the development and maintenance of male secondary sexual characteristics and anabolic effects such as increased muscle mass and bone density.
Administration[edit | edit source]
The intramuscular form of testosterone undecanoate is typically injected into the gluteal muscle. The oral form should be taken with food to enhance absorption. Dosage and frequency of administration depend on the individual's condition and response to treatment.
History[edit | edit source]
Testosterone undecanoate was first introduced in the 1970s. It has since become a widely used form of testosterone replacement therapy due to its long-acting nature and effectiveness.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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