Tetrahydrogestrinone

Tetrahydrogestrinone (THG), also known as The Clear, is a synthetic and orally active anabolic steroid developed and used for performance enhancement. It was first identified in 2003 by the United States Anti-Doping Agency (USADA) and is known for its use in high-profile doping scandals in professional sports.

History

THG was first synthesized by Patrick Arnold, a chemist working for the Bay Area Laboratory Co-operative (BALCO). It was designed to be undetectable by standard drug tests and was distributed to professional athletes by BALCO. The substance came to public attention in 2003 when a syringe containing THG was sent anonymously to USADA, leading to a wide-ranging investigation into doping in professional sports.

Pharmacology

THG is a progestin, a type of hormone that plays a role in the menstrual cycle and pregnancy. It is structurally similar to other anabolic steroids like gestrinone and trenbolone, but has been modified to make it orally active and undetectable in urine tests. The exact mechanism of action of THG is not fully understood, but it is believed to promote muscle growth and recovery by binding to and activating androgen receptors.

Health effects

The use of THG has been associated with a range of adverse health effects, including liver damage, cardiovascular disease, and reproductive disorders. Due to its potency and the lack of scientific research on its effects, it is considered a high-risk substance for athletes to use.

Legal status

In many countries, including the United States, THG is classified as a controlled substance and its use is banned in professional sports. Athletes found to have used THG can face sanctions including disqualification and suspension.

See also

• Doping in sport
• Anabolic steroid
• Performance-enhancing substances