Gestrinone
Synthetic steroid with antiestrogenic and antiprogestogenic properties
Gestrinone is a synthetic steroid with both antiprogestogen and antigonadotropin properties. It is primarily used in the treatment of endometriosis, a condition where tissue similar to the lining inside the uterus grows outside the uterus, causing pain and potentially leading to infertility.
Pharmacology[edit | edit source]
Gestrinone acts as an antagonist of the progesterone receptor and has weak androgenic and anabolic effects. It also exhibits antigonadotropic activity, which leads to a reduction in the production of gonadotropins and subsequently decreases the levels of estrogen and progesterone in the body. This hormonal modulation is beneficial in the management of endometriosis, as it helps to reduce the growth and activity of endometrial tissue.
Mechanism of Action[edit | edit source]
Gestrinone binds to the progesterone receptor, inhibiting the effects of progesterone. This inhibition leads to a decrease in the proliferation of endometrial tissue. Additionally, by reducing gonadotropin secretion, gestrinone lowers estrogen levels, which further contributes to the suppression of endometrial growth. The androgenic activity of gestrinone may also play a role in its therapeutic effects, although this is not fully understood.
Clinical Use[edit | edit source]
Gestrinone is administered orally and is typically prescribed for the treatment of endometriosis. The usual dosage regimen involves taking the medication twice a week. The treatment duration and specific dosage may vary based on the severity of the condition and the patient's response to therapy.
Side Effects[edit | edit source]
Common side effects of gestrinone include acne, weight gain, hirsutism, and voice deepening. These effects are primarily due to its androgenic properties. Other potential side effects include menstrual irregularities, hot flashes, and mood changes.
Contraindications[edit | edit source]
Gestrinone is contraindicated in patients with known hypersensitivity to the drug, as well as in those with severe liver dysfunction, pregnancy, and breastfeeding. It is also not recommended for use in patients with a history of thromboembolic disorders.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD