Antigonadotropin

Antigonadotropin is a type of hormone that inhibits the production and effects of gonadotropins. Gonadotropins are hormones produced by the anterior pituitary gland that stimulate the gonads (the ovaries and testes).

Mechanism of Action

Antigonadotropins work by blocking the receptors for gonadotropins on the gonads, preventing these hormones from stimulating the gonads to produce sex hormones and gametes (eggs and sperm). This can be useful in certain medical conditions where it is desirable to reduce the production of sex hormones or gametes.

Uses in Medicine

Antigonadotropins are used in a variety of medical conditions. They can be used to treat endometriosis, a condition where tissue similar to the lining of the uterus grows outside the uterus, causing pain and sometimes infertility. By reducing the production of sex hormones, antigonadotropins can help to shrink these growths and reduce symptoms.

They are also used in the treatment of prostate cancer, as reducing the levels of sex hormones can help to slow the growth of the cancer. In addition, they can be used in gender dysphoria as part of hormone therapy to help individuals transition to their identified gender.

Side Effects

Like all medications, antigonadotropins can have side effects. These can include hot flashes, fatigue, mood changes, and decreased sexual desire. In addition, long-term use can lead to bone loss, which can increase the risk of osteoporosis.

See Also

• Hormone therapy
• Endocrine system
• Gonadotropin-releasing hormone