Tezacitabine
Tezacitabine is a nucleoside analog that has been studied for its potential use in cancer treatment. It is a synthetic compound designed to interfere with the DNA synthesis of rapidly dividing cells, making it a candidate for chemotherapy.
Mechanism of Action[edit | edit source]
Tezacitabine works by incorporating itself into the DNA of cancer cells during the DNA replication process. This incorporation leads to the termination of DNA chain elongation, ultimately causing cell death. The drug targets the S phase of the cell cycle, where DNA synthesis occurs, making it particularly effective against rapidly proliferating cancer cells.
Clinical Trials[edit | edit source]
Tezacitabine has undergone various clinical trials to evaluate its efficacy and safety. These trials have included both preclinical studies and Phase I, Phase II, and Phase III clinical trials. The results have shown promise in treating certain types of solid tumors and hematologic malignancies.
Side Effects[edit | edit source]
As with many chemotherapy agents, Tezacitabine is associated with a range of side effects. Common side effects include:
Related Compounds[edit | edit source]
Tezacitabine is part of a broader class of drugs known as nucleoside analogs, which also includes:
Research and Development[edit | edit source]
Research on Tezacitabine is ongoing, with studies focusing on optimizing its efficacy, reducing side effects, and exploring combination therapies with other anticancer agents. The drug is also being investigated for its potential use in treating other diseases beyond cancer.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
