Tolbutamide

Tolbutamide is an oral hypoglycemic agent used for the treatment of type 2 diabetes. It belongs to the sulfonylurea class of drugs, which are insulin secretagogues. Tolbutamide works by stimulating the release of insulin from the pancreas, thereby lowering blood glucose levels.

Pharmacology[edit | edit source]

Tolbutamide is a sulfonylurea oral hypoglycemic agent. It works by stimulating the release of insulin from the pancreas. This action is dependent upon functioning beta cells in the pancreatic islets. Tolbutamide is extensively metabolized in the liver, primarily to hydroxytolbutamide.

Clinical Use[edit | edit source]

Tolbutamide is used in the management of type 2 diabetes when diet alone is not adequate to control blood sugar levels. It is usually used in conjunction with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes.

Side Effects[edit | edit source]

Common side effects of tolbutamide include nausea, upset stomach, and skin rash or itching. More serious side effects can include low blood sugar (hypoglycemia), jaundice, and thrombocytopenia.

Contraindications[edit | edit source]

Tolbutamide is contraindicated in patients with known hypersensitivity to sulfonylureas, in patients with type 1 diabetes or diabetic ketoacidosis, and in patients with severe renal or hepatic insufficiency.

Interactions[edit | edit source]

Tolbutamide may interact with other drugs, including beta blockers, which can mask the symptoms of hypoglycemia, and certain antibiotics, which can increase the risk of hypoglycemia.

See Also[edit | edit source]

Tolbutamide Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.