Topilutamide

Topilutamide (also known as Fluridil) is a nonsteroidal antiandrogen (NSAA) that is used topically in the treatment of androgenic alopecia (male-pattern baldness). It is a derivative of bicalutamide, a drug that is used in the treatment of prostate cancer. Topilutamide is not approved for use in the United States, but it is available in some European countries.

Pharmacology

Topilutamide acts as a selective antagonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). By blocking the action of these hormones at the AR, topilutamide can prevent androgen-dependent hair loss.

Clinical use

Topilutamide is used in the form of a topical solution that is applied to the scalp. It has been found to be effective in the treatment of androgenic alopecia in clinical studies, with improvements in hair count and patient self-assessment scores. The drug is generally well tolerated, with side effects being rare and mild.

See also

• Androgen receptor antagonist
• Androgenic alopecia
• Nonsteroidal antiandrogen

References

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