Transient acantholytic dermatosis

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Transient acantholytic dermatosis (also known as Grover's disease) is a skin condition characterized by the sudden onset of itchy red spots, primarily on the trunk. It is a benign but often uncomfortable condition that typically affects middle-aged and older adults.

Presentation

The primary symptom of transient acantholytic dermatosis is the appearance of small, red, itchy papules on the chest, back, and occasionally other areas of the body. These lesions may be accompanied by a burning or stinging sensation. The condition is often exacerbated by heat, sweating, and sun exposure.

Pathophysiology

The exact cause of transient acantholytic dermatosis is unknown. However, it is believed to be related to sweat gland dysfunction and may be triggered by heat, sweating, and dry skin. Histologically, the condition is characterized by the presence of acantholysis, which is the loss of connections between keratinocytes in the epidermis.

Diagnosis

Diagnosis is typically made based on the clinical appearance of the lesions and patient history. A skin biopsy may be performed to confirm the diagnosis, revealing characteristic findings such as acantholysis and dyskeratosis.

Treatment

Treatment options for transient acantholytic dermatosis are aimed at relieving symptoms. These may include:

• Topical corticosteroids to reduce inflammation and itching.
• Antihistamines to alleviate itching.
• Avoidance of triggers such as heat and sweating.
• Use of emollients to keep the skin moisturized.

In some cases, the condition may resolve spontaneously without treatment.

Prognosis

The prognosis for transient acantholytic dermatosis is generally good, as it is a self-limiting condition. However, it can be recurrent and chronic in some individuals.

Epidemiology

Transient acantholytic dermatosis most commonly affects middle-aged and older adults, with a higher prevalence in men. The condition is relatively rare and is more frequently observed in individuals with a history of atopic dermatitis or other skin conditions.

See also

• Dermatology
• Skin lesion
• Acantholysis
• Pruritus