Trepibutone

Trepibutone

Chemical structure of Trepibutone

Trepibutone is a pharmaceutical drug used primarily for its choleretic and spasmolytic properties. It is commonly prescribed to alleviate symptoms associated with gastrointestinal disorders, particularly those involving the biliary tract.

Pharmacology

Trepibutone acts by stimulating the secretion of bile from the liver, thereby enhancing the digestion and absorption of lipids. It also exerts a relaxing effect on the smooth muscles of the gastrointestinal tract, which helps in reducing spasms and alleviating pain associated with biliary colic.

Mechanism of Action

The exact mechanism of action of Trepibutone is not fully understood, but it is believed to involve the modulation of calcium channels in smooth muscle cells, leading to muscle relaxation. Additionally, it may influence the autonomic nervous system to promote bile flow.

Clinical Uses

Trepibutone is indicated for the treatment of:

• Biliary dyskinesia
• Cholecystitis
• Cholelithiasis (gallstones)
• Irritable bowel syndrome (IBS) with predominant pain and spasm

Side Effects

Common side effects of Trepibutone may include:

• Nausea
• Diarrhea
• Dizziness
• Headache

Serious side effects are rare but can include allergic reactions such as rash, itching, and swelling.

Dosage and Administration

Trepibutone is typically administered orally in the form of tablets. The dosage and duration of treatment depend on the specific condition being treated and the patient's response to the medication. It is important to follow the prescribing physician's instructions carefully.

Related Pages

• Choleretic
• Spasmolytic
• Biliary tract
• Gastrointestinal tract