Trestolone

Trestolone, also known as 7α-methyl-19-nortestosterone (MENT), is a synthetic androgen and anabolic steroid that is used in hormone replacement therapy and as a contraceptive. It is a derivative of nandrolone, a naturally occurring steroid hormone in the body.

History[edit | edit source]

Trestolone was first synthesized in the 1960s. It was developed as a potential therapeutic agent for the treatment of male hypogonadism and contraception. However, it was not until the 1990s that the potential of Trestolone for these applications was fully realized.

Pharmacology[edit | edit source]

Trestolone is a potent androgen and anabolic steroid. It has a high affinity for the androgen receptor, which is the primary mechanism through which it exerts its effects. Trestolone also has a high degree of resistance to the enzyme 5α-reductase, which converts testosterone into dihydrotestosterone (DHT). This makes Trestolone more potent than testosterone and less likely to cause certain side effects associated with DHT.

Medical uses[edit | edit source]

Trestolone is used in hormone replacement therapy for men who have a deficiency or absence of endogenous testosterone. It is also being investigated as a potential male contraceptive, due to its ability to suppress spermatogenesis.

Side effects[edit | edit source]

Like all androgen and anabolic steroids, Trestolone can have side effects. These can include acne, hair loss, gynecomastia, and changes in mood or behavior. However, due to its resistance to 5α-reductase, Trestolone may have a lower risk of certain side effects compared to other steroids.